Later he decided to continue his education and tried himself at the University of Wisconsin–Madison, but left it after first semester. He enrolled in the Princeton University in the 1973 and studied applied mathematics.

In the 1976 he finally received a Ph. D. Degree. After Princeton he held a fellowship at Harvard University during 1976-1977. The next year he visited Oxford University and at the end of 70s was involved as held a fellowship at Harvard University.

In the 1981, he proved the positive energy theorem in general relativity and later was awarded for that experiment. At the end of 80s, he coined the term of topological quantum field theory for a certain type of physical theory. He also realized that theory which titled Chern–Simons theory will provide a framework for understanding the mathematical theory of knots as well as a 3-manifolds.

In the 1995 by working with the string theory, he made his own brave suggestion that five different string theories were not distinct theories in real, he said that it was different limits of one theory which he called "M-theory". He also made a contribution to physics with a case of gauge/gravity duality.

It happens in the 1997, when another scientist Juan Maldacena announced his results as AdS/CFT correspondence. Along with Nathan Seiberg, Edward made other results during the time he studied certain noncommutative quantum field theories that arise as limits of string theory. In the end he developed Seiberg–Witten invariants.

He has started his scientific work since the end of the 60s, when he wrote his first articles, which was published in such journals like “The New Republic ” and “The Nation”. For his incredible contributions, in the 1990 he was awarded the Fields Medal by the International Mathematical Union, in fact, he was the first physicist who won this prize.

In the 2004 he became a Nobel Prize laureate in Physics. For the years of his successful scientific career, he got numerous of awards and prizes like “Pythagoras Award (2005)”, “Nemmers Prize in Mathematics (2000)”, “Henri Poincaré Prize (2006)” and “Fundamental Physics Prize (2012)”. He also was a member of the Pontifical Academy of Sciences and a Foreign Member of the Royal Society in the 1999.

He is married to Chiara Nappi. His wife is a physicist. She is of Italian descent. The couple has three beautiful children, named Ilana, Daniela, and Rafael. His daughters are scientists too. Once in an interview he said that religion is very important for him. His net worth is still under evaluating.