Debra Messing was born in Brooklyn to Brian, who has worked as a sales executive for a costume jewellery packaging manufacturer and Sandy Messing, a professional singer and real estate agent, on August 15, 1968. The sensual and versatile actress attended Brandeis University doing Bachelor of Arts, later she joined New York University in order to pursue master degree in Arts.

Hailing from the musical family background, Messing was more fascinated towards acting rather than singing. Even though Debra is blessed with a beautiful and melodious voice, she chosen acting field rather than making a career out of singing.

The stunning actress made her presence with her sensual performance while playing as the latter half of television's Will and Grace. In 1993, Debra won praise for her acting in the workshop production of Tony Kushner's play ‘Angels in America: Perestroika’. Subsequently, Debra appeared in several television series episodes ‘NYPD Blue’ during 1994 and 1995. Debra made her debut in films by playing the unfaithful wife of main character Paul Sutton in Alfonso Arau's ‘A Walk in the Clouds’. From there on Debra Messing has acted in number of movies later, which became sensational hit. Debra has played a variety of roles like a supporting role in ‘Along Came Polly’, then a leading role in ‘The Wedding Date and Nothing Like the Holidays’. Adding to her filmography career, Debra has also acted in hit television shows like NYPD Blue (1994), Seinfeld (1996), Will & Grace (1998), Project Runway and The Mysteries of Laura.

Debra Messing was one of the “50 most Beautiful People in the World” which was declared by People in 2002 and was “Best Dressed Women” prefer by TV guide in 2003. She has got a total of six Emmy nominations, in which she won one, and eight screen actors’ guild nominations, winning one and eight golden globe nomination.

Debra married to her ex-boyfriend Daniel Zelman, who is a screenwriter; they both met first time in the day of graduation from New York University in the year 1990. She was blessed with a son, Roman Walker on April 7, 2004. She got separated from her husband after 11 years of marriage.

While she was pregnant, Messing gained 60 Pounds. Debra used to fast food and candies all the time, and this poor diet caused her weight gain, and other problems like acne and dry hair, so she transformed her diet, and worked on losing weight. Now Debra Messing looks and feels great after her recent 20-pound weight loss on a healthy diet but still she craves many of her old favourite foods.

Currently Debra is residing as single women and there is no news about her being involved in any dating thing or having an affair with anyone. With personal interest lending to involvement with such organizations as the Best Friend's Pet Sanctuary, Gay Men's Health Crisis, and AmfAR, the actress uses much of her personal time to encourage social awareness of HIV and AIDS related issues and also encourage people to adopt pets.