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David Baltimore was born in 1938 in New York City to Richard Baltimore and Gertrude Baltimore. He was raised in the Queens neighborhoods of Rego Park and Forest Hills before his family moved to suburban Great Neck, New York. The relocation was prompted by his mother's belief that the local schools offered superior educational opportunities. He completed his secondary education at Great Neck High School in 1956.
During high school, Baltimore developed a strong interest in biology, which was further shaped by a formative summer experience at the Jackson Laboratory in Bar Harbor, Maine. He went on to earn his bachelor's degree with high honors from Swarthmore College in 1960. While there, he was mentored by George Streisinger, whose guidance helped cultivate Baltimore’s passion for molecular biology.
David Baltimore was awarded the Nobel Prize in Physiology or Medicine in 1975, alongside Renato Dulbecco and Howard Temin. The honor recognized their groundbreaking discoveries related to the interaction of tumor viruses with the genetic material of cells, a milestone in the fields of virology and cancer research. Baltimore's work significantly contributed to the understanding of reverse transcription and its implications for molecular biology.
Baltimore's scientific contributions include pivotal work in recombinant DNA technology, immunology, and biotechnology. Over the course of his career, he has mentored numerous postdoctoral fellows and doctoral students, many of whom have gone on to become distinguished researchers in their own right.
In recognition of his lifelong impact on science and education, Baltimore received the U.S. National Medal of Science in 1999, among multiple other prestigious awards.
David Baltimore served as president of Rockefeller University from 1990 to 1991. He later assumed the position of president at the California Institute of Technology (Caltech) in 1998, a role he held until 2006. Currently, he holds the titles of President Emeritus and Robert Andrews Millikan Professor of Biology at Caltech.
In 2007, he served as president of the American Association for the Advancement of Science (AAAS), reflecting his continued influence on science policy and education at an international level.
Baltimore is the current Chair of the Board of Sponsors for the Bulletin of the Atomic Scientists, an organization that addresses global security issues involving science and technology. Additionally, he serves as a consultant to the Science Philanthropy Alliance, further extending his leadership and advisory influence in scientific funding and innovation.
David Baltimore married Dr. Alice S. Huang in 1968, herself an accomplished molecular biologist. The couple has one daughter. Though raised observing Jewish holidays and attending synagogue with his father, Baltimore was influenced by both religious and secular perspectives in his upbringing—his father practiced Orthodox Judaism while his mother identified as an atheist.
In the early 1990s, Baltimore was indirectly involved in a highly publicized scientific misconduct case related to researcher Thereza Imanishi-Kari. Although he was not implicated in wrongdoing, Baltimore drew attention for his public defense of Imanishi-Kari during a congressional investigation. No evidence of misconduct was ultimately found, and Baltimore's professional standing remained intact.
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