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Stanley Benjamin Prusiner was born on May 28, 1942, in Des Moines, Iowa, to Miriam (Spigel) and Lawrence Prusiner. His father was an architect. Prusiner spent most of his early years in Cincinnati, Ohio. He attended Walnut Hills High School, where he earned a reputation as a gifted student. As a teenager, he impressed teachers with an innovative science project that involved developing a repellent for boxelder bugs.
Prusiner pursued his undergraduate education at the University of Pennsylvania, where he earned a Bachelor of Science degree in chemistry. He continued at the University of Pennsylvania School of Medicine, obtaining his M.D. degree.
After medical school, Prusiner moved to California and began an internship in medicine at the University of California, San Francisco (UCSF). His growing interest in research led him to the National Institutes of Health (NIH), where he worked in the laboratory of biochemist Earl Stadtman. During his three years at the NIH, Prusiner studied glutaminases in E. coli, gaining valuable biochemical research experience.
Following his tenure at the NIH, Prusiner returned to UCSF to complete a residency in neurology. In 1974, he joined the faculty of UCSF's Department of Neurology, where he remained professionally based for decades.
Over the years, Prusiner held academic positions at both the University of California, Berkeley, and UCSF. He is currently the director of the Institute for Neurodegenerative Diseases at UCSF. His pioneering research has focused on neurodegenerative disorders, particularly those involving prions—a unique class of infectious, self-replicating proteins.
Prusiner began his groundbreaking research on prions in the early 1970s. Working with collaborators including D. P. Stites, W. J. Hadlow, D. E. Garfin, and C. W. Eklund, he proposed a novel infectious agent—what he later termed a "prion"—to explain the cause of transmissible spongiform encephalopathies. This concept helped elucidate the pathology behind diseases such as bovine spongiform encephalopathy (BSE or "mad cow disease") and its human counterpart, Creutzfeldt–Jakob disease.
His research significantly advanced understanding of neurodegeneration and contributed to new approaches targeting prion diseases, as well as Alzheimer's disease and other tauopathies. In recognition of his contributions, he was elected to the National Academy of Sciences in 1992.
Prusiner has received numerous honors throughout his career. He was awarded the Richard Lounsbery Award by the National Academy of Sciences in 1993 for outstanding achievements in biology and medicine. That same year, he received the prestigious Dickson Prize in Medicine.
In 1997, Prusiner was awarded the Nobel Prize in Physiology or Medicine for his discovery of prions. Additional accolades include the Benjamin Franklin Medal from the Franklin Institute in 1998 and the Keio Medical Science Prize. He was also honored with the National Medal of Science, further reflecting his influence on neuroscience research.
According to Google Scholar, Prusiner has made a significant impact on scientific literature, with numerous highly cited publications that continue to shape the field of neurodegenerative disease research.
Stanley Prusiner is married to Sandy Turk Prusiner, and together they have two children. He maintains a relatively low profile and is not active on social media. Information regarding his personal financial status is not publicly available, in keeping with his private lifestyle.
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