In 1994, Mello joined the faculty of the University of Massachusetts Medical School. His research interests soon turned toward gene silencing via RNA injection. While working in this area, he collaborated with Andrew Z. Fire at the Carnegie Institution for Science in Washington, D.C. Together, they co-discovered RNA interference (RNAi)—a natural cellular mechanism that can silence specific genes.
This discovery revealed that introducing double-stranded RNA into a cell could trigger the degradation of corresponding messenger RNA (mRNA), effectively "silencing" the gene. Their research also showed that this silencing effect could be inherited by the next generation—a finding with profound implications in both developmental biology and disease research. For their pioneering work, Mello and Fire were jointly awarded the Nobel Prize in Physiology or Medicine in 2006.
The discovery of RNAi has become an invaluable tool in genetic research, allowing scientists to selectively inhibit gene expression to investigate individual gene functions and their roles in diseases such as cancer, AIDS, and hepatitis. The technique holds promise for targeted therapies and gene-based treatments.
In recognition of his significant scientific contributions, Craig Mello was named a Howard Hughes Medical Institute Investigator. Over the course of his career, he has received numerous awards and honors for his work in molecular biology and genetics. While his exact net worth is not publicly disclosed, Mello remains an influential figure in the field of biomedical research.
Return to the previous page| Birth Date: | 18 Oct, 1960 |
| Age: | 59 yrs |
| Occupations: | Biologist Biochemist Physician Professor |
| Citizenship: | United States of America |
| Birth Place: | New Haven |
| Education: | Harvard University Brown University |
| Gender: | Male |
| Description: | American biologist |
