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Born Justin William Chambers on January 16, 1970, the American actor and former fashion model is best known for his role as Dr. Alex Karev in the long-running ABC medical drama, Grey’s Anatomy. Chambers’ portrayal of Karev earned him critical acclaim and widespread popularity across a global audience.
Justin Chambers was born and raised in Springfield, Ohio. He is the son of John William Eugene Chambers II and Pamela Sue Chambers, both of whom worked for the Springfield police department. He has a fraternal twin named Jason, along with three other siblings: an older brother, John Jr., and two older sisters, Mia and Susan. As a child, his twin brother suffered from recurring bouts of pneumonia, which influenced the family’s focus on health.
Chambers attended Southeastern High School in South Charleston, Ohio, before later pursuing a career in entertainment.
Chambers was discovered by a modeling scout while on vacation in Paris, which led to a successful modeling career. He became the face of several high-profile fashion campaigns, including Calvin Klein’s fragrance line, and worked with renowned brands such as Armani and Dolce & Gabbana, traveling extensively across Europe, Japan, and the United States.
Eventually, Chambers shifted his focus toward acting and moved to New York City, where he studied at the HB Studio and Ron Stetson Studios for professional acting training. He began his acting career with minor roles in television, including a part as Nicholas Hudson in the soap opera Another World and a guest appearance on New York Undercover. In 1998, he starred in the CBS miniseries Four Corners, although the show was short-lived.
Chambers built his résumé with performances in TV films such as Rose Hill, Harvest of Fire, and Seasons of Love. His film career includes roles in Liberty Heights, The Wedding Planner, The Musketeer, The Zodiac, and Southern Belles.
Chambers' career reached new heights in August 2004 when he was cast as Dr. Alex Karev in ABC’s hit medical drama Grey’s Anatomy. The series debuted in 2005 and quickly became a cultural phenomenon. Chambers was part of the original cast and remained a central figure on the show for 16 seasons until his departure in 2020. His nuanced portrayal of Karev contributed to the show’s success and longevity.
During his tenure, the cast won the Screen Actors Guild Award for Outstanding Performance by an Ensemble in a Drama Series. In 2009, Chambers made a guest appearance in Private Practice, a spin-off from Grey’s Anatomy, cementing his versatility and popularity. By 2007, following contract negotiations, Chambers reportedly earned a salary of $125,000 per episode—a testament to his value to the series and its producers.
Justin Chambers married Keisha Chambers, a former model agency booker, in 1993. The couple has five children: Isabella, twins Maya and Kaila, Eva, and Jackson. Known for keeping his family life private, Chambers and his wife maintain a relatively low profile despite his public career.
In interviews, Chambers has spoken openly about his challenges with sleep disorders, including insomnia, which at one point required treatment at UCLA Medical Center in Los Angeles. His transparency about his health struggles has highlighted the pressures of the entertainment industry and added dimension to his public persona.
In recent years, Chambers has appeared less frequently on television but continues to make occasional guest appearances on soap operas and other TV shows, staying active in the industry while focusing on his well-being and family life.
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