She also gained widespread recognition for her performances in popular television sitcoms. From 2011 to 2015, McCoy starred in Single Ladies as Keisha Green, a video model turned semi-professional poker player who approaches relationships through intellect and strategy. Earlier, she was cast as Neesee James in All of Us, where she portrayed the ex-wife of a television entertainment reporter navigating co-parenting. The show was loosely inspired by the blended family experiences of creators Will Smith and Jada Pinkett Smith.

In addition to these roles, McCoy starred in her own reality television show, LisaRaye: The Real McCoy, which explored her life behind the cameras.

First Lady of the Turks and Caicos Islands

In 2006, LisaRaye married Michael Misick, then Premier of the Turks and Caicos Islands. Upon their marriage, she paused her acting engagements and moved to the islands to fulfill her duties as First Lady. However, the marriage ended in divorce by 2008.

In a widely viewed interview with Oprah Winfrey, McCoy revealed that the marriage deteriorated due to infidelity and allegations of corruption involving her husband. She emphasized that her values, shaped by her own success and upbringing, conflicted with Michael's alleged misconduct. When she was expected to testify in the corruption investigations, the already-strained relationship ended conclusively.

Michael Misick later faced legal consequences in connection with corruption charges during his tenure as Premier.