He began to play football for his hometown club Post SV Dortmund in 1994 and joined the youth ranks of Borussia Dortmund in 1996. He played for Borussia Dortmund until he left for the U-19 of Rot Weiss Ahlen in the summer of 2006. He was featured in five games for the club's second team, which played in the Westphalia league at the time. He scored a goal in each of his first two games.

The following year he was able to break into Ahlen's first team, which played in the German third division at the time. He started twice and was featured in 14 matches, scoring two times. In 2008–09, he had his definitive breakthrough as a professional football player. He played in 27 games and scored four times. On 25 May 2009, he signed a four-year contract with Bundesliga club Borussia Mönchengladbach. In 2009 Reus scored his first Bundesliga goal in a game against Mainz.

At the start of the 2011–12 season, Reus scored seven goals in twelve matches. Reus' contract with Gladbach was set to expire in 2015 and reportedly had a buy-out clause of €18 million. In 2012, Reus signed with his former club Borussia Dortmund for a transfer fee of €17.1 million on a five-year deal that will keep him at the club until July 2017.

Reus officially re-joined Dortmund on 1 July 2012. On 29 September, Reus scored two goals for Dortmund in a 5–0 rout of his former club Borussia Mönchengladbach, pushing the champions to the top of the Bundesliga table through six games. On 3 October, in Reus' first ever Champions League appearance, he opened the scoring as Dortmund earned a 1–1 draw away to Premier League champions Manchester City.

In Dortmund's following Champions League match, on 21 November, Reus scored Dortmund's first goal in a 4–1 defeat of AFC Ajax at the Amsterdam Arena. In 2013, Reus scored a hat trick, netting all the goals in Dortmund's thumping of Hessen side Eintracht Frankfurt. Reus also made his under-21 team debut in a friendly match against Turkey. On 22 June, he scored in the UEFA Euro 2012 quarterfinal against Greece, his first start for Germany in the tournament.

As for the personal life in his biography, Reus dated Caroline Bohs, a German TV presenter, in 2009. He and his girlfriend broke up in 2013 but they remain close friends. Reus started dating German model Scarlett Gartmann in December 2015. Marco Reus is also a trendsetter and his haircut is an example for millions all over the world to emulate. The German International has the ability to pull off both long and short haircuts with confidence and spends a lot of time on getting the exact right look. His net worth is about $20 million and his salary is $6 million.