He has worked on several movies and television shows. In the year 1996, he has worked in the movie named as Favorite Deadly Sins. In the year 1998, the actor again worked for another movie called as Tomorrow Night. After a three years gap, Conan got a chance to work in the movie Pootie Tang in the year 2001. In 2001, some other movies of him were also released titled as Pootie Tang, Vanilla Sky, and Storytelling. Again in the year 2003, Conan was seen in the documentary movie End of the Century: The Story of the Ramones and in 2005, he worked for the film Bewitched. The year 2006 brought luck to him and he could work in two good movies named as Queer Duck: The Movie and the Pittsburgh. Conon was also seen in the film The Great Buck Howard in the year 2008 and after three years gap, Conon got a chance to work for the documentary film Conan O'Brien Can't Stop in the year 2011. The year 2013 proved to be a blessing for him and he was signed for three movies namely Batman: The Dark Knight Returns Part 2 as David Endocrine, the Now You See Me, the Clear History and The Secret Life of Walter Mitty. He had also worked in the movie named as Sharktopus vs. Pteracuda in the year 2014.

Conon is also a good Executive Producer and has produced few good films such as the episodes of The Simpsons that was telecasted between the year 1991 and 1993. In the year 2007, he has also produced the 6 episodes of Andy Barker, P.I. Again in 2011 till date, he is working on the project Eagleheart. Prior to this, he has produced films like Deon Cole's Black Box (6 episodes), Super Fun Night (17 episodes), The Pete Holmes Show (80 episodes) and The Jack and Triumph Show.

As a writer, he has written 13 episodes for Not Necessarily the News show that was telecasted between the year 1983 to 1987, and 73 episodes of Saturday Night Live from 1987 to 1991. He has also written for The Simpsons (4 episodes) and Andy Barker, P.I (6 episodes). He has been a winner of the series Late Night with Conan O'Brien in the year 1997 under the category of the comedy show. He was also the winner of the Telvis Award in the year 2006 under the category of Color Spot of the Year.

Moving towards his biography, he is of 1.93 m height. He is married to the actress Elizabeth Ann 'Liza' Powel. They got married in the year 2002 on 12th January. He lives with his wife and his daughter Neve and son Beckett.