Dybala's grandmother named Da Messa, was from Naples, Italy. His grandmother was from Italy and so he has Italian origin as well. Paulo oficially obtained his Italian citizenship on August of 2012.  

Paulo started playing football at a very young age. His parents have always been supportive of his career. He was a very gifted player and it started to show once he got the ball. He was very skilled player for a player of his age.

He played in small leagues in school and colleges before going professional in 2010 at the age of 17 years old, when he started playing for the Argentinian club Primera B Nacional. He played for the club as a striker and scored 17 goals for the club in his first season. He was the youngest player to score a goal at the time, beating a then record of Mario Kempes. Paulo was also the first to play 38 consecutive games in a professional league, once again beating another Mario Kempes record. Paulo had scored in 6 consecutive games, beating a old record of four games. He also scored 2 hat tricks in the season. All of this made him an unbelievable player for his age and people all over the world began to take notive of the new phenom nicknamed "La Joya". His performances started attracting interest from coaches all around Argentina and from the clubs in Europe as well.

In 2012 he was contacted by the Italian club Palermo. Dybala saw a chance to increase his skill and so he joined the club. He started with the club in 2012 scoring a brace in his fourth match for the club. His tactical play and skill set were very important for the club to stay in the top half of the league. At this point in time, the other European clubs were looking at him like scavengers as he was proving to be a very good player for his age. Paulo made his debut for Palermo in a Serie A match against Lazio. Paulo obtained his first two goals in Italy on November 11, 2012 when they beat the team Sampdoria at home 2 to 0. 

It wasn't until 2014-2015 that Paulo had his breakout season. He scored 10 goals in the first half of the season alone. He also formed a very successful duo with fellow striker Franco Vazquez, who is Argentine and Italian. Paulo finished the season with 13 goals and 10 assists. This made him one of the best assist providers in the league.

He was regarded as the new Messi as he is from the same country as the little magician. He stayed with the club for 3 years and in 2015 he signed for the Italian giants Juventus amid many transfer speculation that connected him to every major club in the world. His decision was influenced by the fact he wanted to stay in Italy and Juventus was the best club in Italy which made his mind very clear. He was also linked with Real Madrid who was ready to pay the club Palermo around $50 million for the service of the player but Dybala made his mind of staying in Italy and that's what he did.