• Mr. Destiny (1990) as Cindy Jo Bumpers
• One Good Cop (1991) as Rita Lewis
• Freejack (1992) as Julie Redlund
• Lethal Weapon 3 (1992) as LAPD Sgt. Lorna Cole
• In the Line of Fire (1993) as Secret Service Agent Lilly Raines
• Major League II (1994) as Lynn Wells
• Outbreak (1995) as Robby Keough
• Get Shorty (1995) as Karen Flores
• Tin Cup (1996) as Dr. Molly Griswold
• Buddy (1997) as Mrs. Gertrude Lintz
• Lethal Weapon 4 (1998) as Lorna Cole-Riggs
• Two for the Money (2005) as Toni Morrow
• Yours, Mine and Ours (2005) as Helen North
• Thor (2011) as Frigga
• The Intern (2015) as Fiona

One of her most critically acclaimed roles was as Nina Romina in the 2014 film Nightcrawler, a performance for which she received multiple award nominations. She is also noted for her role as Natasha Fatale in the 2000 film The Adventures of Rocky and Bullwinkle.

Personal Life and Net Worth

Rene Russo has been married to screenwriter and director Dan Gilroy since 1992. The couple has one daughter, Rose Gilroy, born in 1993. They reside in the Brentwood neighborhood of Los Angeles, California. Over the span of her successful acting and modeling career, Russo has amassed an estimated net worth of $40 million.