Sherri has 2 sisters and she is the eldest among them. She moved to Hoffman Estates with her family at a young age. Her family wasn’t wealthy; her mother used to work as a maid and clean others’ homes while her father worked at Sambos restaurant as a service manager.

She began working as a legal secretary in Beverly Hills in 1990. She always wanted to work as a comedian and ultimately in 1995, decided to quit her job to fulfil her dreams. This step in her career finally bore fruit, since she got a job as a regular in the first series of WB's ‘Cleghorne! ‘, just after 12 days. Unfortunately for Sherri, the show lasted only for a single season. She didn’t get any other shows at that point, so she was compelled to move back to her old job in the law firm where she worked for another 3 years.

She is running a successful business in 2015, which deals with wigs and hair add-ins. She also acted in a sitcom named after her own name ‘Sherri’ which is even based on her personal life. She even made a guest appearance in ‘Who Wants to Be a Millionaire’.

She often used to guest co-host 'The View' on ABC in 2006, and started co-hosting full time from next year. This show continued till 2014. She was applauded for her brilliant performances in that show and even received several awards. She also co-hosted the Emmy Awards in 2008. She often used to guest star in the extremely popular TV show ’30 Rock’ as Tracy Morgan’s wife, Angie Jordan.

Shepherd is also successful as an author; her book 'Permission Slips: Every Woman's Guide to Giving Herself a Break' was published in October, 2009 which earned her a lot of recognition. She also co-authored another book 'Plan D: How to Lose Weight and Beat Diabetes' which was published in 2013 by Harper Collins.

She participated in the 14th season of ‘Dancing with the Stars’ as a celebrity contestant which aired on ABC. She was partnered with Val Chmerkovskiy and lasted for several weeks before getting eliminated.

She has a huge fan following in Twitter and Instagram, and even has her own website. She married twice. Her first husband was Jeff Tarpley. She had a son, Jeffrey with him, who is now eight years old. She was in a relationship with TV writer Lamar Sally. Later in 2010, he proposed to her and they got married the next year. However, in 2014, they filed for a divorce and Sherri was declared the legal parent of her surrogate child.

Sherri Shepherd has a net worth of $10 million, as of 2015.