Jo Beth was born in the state of Texas, in the city of Houston and she is a daughter to Frances Faye who worked as a dietitian and to Fredric Roger Williams who worked as an opera singer and also a manager for a company that deals with wire and cables. He grew up in South Park neighborhood in Houston and she went to Jones High School. She finished the schooling from the Pembroke College of Brown University in the Providence of the Rhode Island in the year 1970 and she wanted to be child psychologist. However, she decided to turn to the theater and she started to train with Jim Barnhill and with John Emigh for Trinity Repertory Company. She took the voice lessons so that she can neutralize Texan accent and afterwards, she went to live in New York City and she starred in some television series in the year 1970s.

Her first role was playing in the Boston produced television series for children called Jabberwocky. Her character was named JoBeth and she was replacing the original hostess called Joanne Sopko.

From her biography, she started the role in the motion pictures in the Stir Crazy and he was with Richard Pryor and Gene Wilder. She is known to work steadily and she was able to transition from the leading lady to start playing mature actress. Her well known movie is when she played as a suburban housewife in a supernatural movie called Pltergeist. She had appeared in many movies and they include from the Earth to the Moon miniseries and she was Marge Slayton a wife to the Deke Slayton. She played in the episodes of Dexter where she was the future mother in law of the serial killer.

She got married to John Pasquin who is a film director and they were together in the Jungle 2 Jungle and they have already two children together. Her net worth is expected to be around 3 million dollars and she does not have any relationship with Gilliam Weber.