Luke Pasqualino was born in Cambridgeshire, in the area called Peterborough and his parents were Italian Descent and were from Naples and Sicily. He went to Walton Community School found in Walton in Peterborough and for the drama classes that were held under Martin Tempest of Stamford Art Centre. He auditioned to be a part of Tony Stonem in the series 1 of Skins; However, British Actor Nicholas Hoult was the one who got this part. Before his appearance in the Skins, he was in different plays and did modeling. He was working in the salon of his father called Image International.  His twitter page is @lucapasqualino and his height is 6 feet and 2 inches.

In the year 2009, Luke Pasqualino started the career when he was acting as the protagonist of the low-budget film called Stingers Rule. It was about the local football team who are against the property developers who wanted to destroy the beloved football ground they had.  He was the guest star in the movies and tv shows called Miranda and causality. In the year 2008, Miranda became the regular of the new series called Skins at E4 for its third season. The program was replacing all the cast members every two season. He was with Freddie McClair who was a laid-back and the weed smoking college pupil.  In the season four, when it was about to end, the cast got replaced.

Luke Pasqualino was the cast in the Warner Bros Pictures for its supernatural horror film called The Apparition together with Ashley Greene of Twilight and  Tom Felton of Harry Potter. The filming started within the same month in both Berlin and Los Angeles and the film got released in 2012. Within the same year, Pasqualino got the recurring role where he was Paolo who was a young servant in the historical drama television series called the Borgias. In the year 2012, he was with Jessica Szohr with Ed Speelers in a romantic werewolf comedy called Love Bite.  

In the year 2011, Luke Pasqualino got the starring role in the Syfy Television pilot called Battlestar and in Galactica: Blood and Chrome. This is the prequel for the reimagined Battlestar in Galactica series.  He was portraying a young version of William Husker Adama in this sequel and it was distributed first in its 10 episodes for the online series at Machinima.com.  Afterwards, he was also played in the French television series called Jo. He was in the ensemble thriller of Snowpiercer and it was examining the train that was full of travelers and they were struggling to live together in the world that it is covered by the snow and ice.