Dubois began his career as a journalist in 1987. His first job was desk assistant for KING-TV. He went on to work as an anchorman and a reporter in Chicago and then landed a position at KCRA-TV in Sacramento, California. Maurice then moved to New York and spent 7 years with WNBC-TV. During this period, he was  co-anchor with Today in New York, a local news program with entertainment for early risers in New York City. Dubois also hosted Four Stories which focused on human interest stories in local communities. He was also working on Mind Over Media, a special show dedicated to students that helped teach media images in television. Dubois also was a substitute to read news on NBC's News Today. 

In the fall of 2004, Dubois made a career move to WCBS-TV, landing a position as anchorman for CBS' News at 6, which he co-hosted with Dana Tyler. He also worked with anchors Mary Calvi and Cindy Hsu. 

In early 2011, Dubois co-hosted CBS 2 News at 5 with his new partner, Kristine Johnson. 

Dubois is also known as for news-breaking reporting; he announced on air the death of Pope John Paul II and was also in Rome when Benedict XVI was elected pope in 2005.DuBois has covered everything from local news to national political conventions, to AIDS in South Africa, to Papal transition at the Vatican, to witnessing a double execution. He has anchored numerous live breaking news stories, and moderated debates for New York City Mayor and Congress. He has also hosted multiple specials on topics ranging from kids and violence, to breast cancer, to ticker-tape parades and telethons.

Surprisingly, Maurice also has a couple of movies in his repertoire appearing in Soul Men in 2008 and Kick-Ass in 2010. 

Dubis left the airwaves due to a battle with Bell's Palsy. Bell's palsy is a temporary form of facial paralysis that impacts once side of the face and can last just a few weeks — as it did with Dubois — or far longer. But he quickly returned after less than a month off. For DuBois, a whole month felt like forever. For two long weeks, he could not move the right side of his face and he spent days wondering if it had been permanently rearranged. But on day 14 came a breakthrough – he could finally make tiny movements. "That's a big deal,” DuBois said the doctor’s office at the time. “It was frozen last week.” The neurologist ran a series of weekly tests to make sure nothing else was going on. DuBois had been through the normal course of steroids and antiviral medication, and afterward, they just waited it out. Week three was very exciting – with baby steps, but more progress. Finally, after a month, there was a huge sigh of relief.