Brenda Buttner was married to Tom Adkins, an American political pundit and a real estate investor, from 2005 and for five years until their divorce in 2010. The couple had two children - Rebecca and Rachel Adkins. The Buttner-Adkins family also had two dogs, Cissy and Buddy. Although the couple was divorced, they both played an equal role raising the two daughters together, fulfilling their needs with the mutual understanding. Due to the lack of information about their lives, and the reason behind their split. we cannot find the exact fact but it is said by the sources that they parted ways saying ‘irreconcilable differences’.

After her divorce, she didn’t get involved with anyone else, but she focused on raising her daughters, and going forward in the career.

Brenda Buttner was diagnosed with a rare type of breast cancer in 2015. She underwent chemotherapy for a while, which caused her to lose weight. However, her sense of humor was still intact and she used to quip, “I wanted to lose a few pounds…well man this chemo diet works!” Unfortunately, she lost the battle against the sickness in 2017, while she was under treatment in the hospital.

Neil Cavuto, the other host of "Your World," paid tribute to Brenda Buttner on his show with these words:

"I have some very sad news to share with you today: Our Brenda Buttner has passed away," he revealed. "Now, many of you know her as the unflappable host of 'Bulls and Bears,' but she was much more. Allow me now to tell you how much more. She was a Rhodes Scholar, but she'd never mention it," he explained. "Near the top of her Harvard class, but she would never ever say it. [...] All that smarts stuff is in her files, but the more important things filled her heart. It's what separated her from everyone else in this business. Not just dollars, you see, Brenda had depth. Let it be known that Brenda Buttner made us want to watch a business show with heart. Her heart, her spirit,” Cavuto said. “She democratized dollars and just made sense.”

Cavuto went on to explain that Buttner had a passion for motorcycles, animals and her two daughters. At one point, she put her career in journalism on hold to edit a motorcycle magazine.